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Apaf-1 Blocking Peptide

Cayman Chemical Item Number 360780

See more	Apoptosis (183)

Description

Each vial contains 200 µg of lyophilized peptide corresponding to amino acids 12 to 28 of human Apaf-1.¹ Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf-1 (for apoptosis protease-activating factor 1).^1,2 Apaf-1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.³ Apaf-1 can also associate with caspase-4 and caspase-8.⁴ Apaf-1 is ubiquitously expressed in human tissues.¹

1 Zou, H., Henzel, W.J., Liu, X., et al. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90 405-413 (1997).

2 Cecconi, F., Alvarez-Bolado, G., Meyer, B.I., et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94 727-737 (1998).

3 Li, P., Nijhawan, D., Budihardjo, I., et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 479-489 (1997).

4 Hu, Y., Benedict, M.A., Wu, D., et al. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA 95 4386-4391 (1998).

Formulation	A lyophilized peptide
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Cecconi, F., Alvarez-Bolado, G., Meyer, B.I., et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94 727-737 (1998).

Li, P., Nijhawan, D., Budihardjo, I., et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 479-489 (1997).

Hu, Y., Benedict, M.A., Wu, D., et al. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA 95 4386-4391 (1998).

Zou, H., Henzel, W.J., Liu, X., et al. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90 405-413 (1997).

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Size	Price	Quantity	Subtotal
200 µg	$107.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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