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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Lyso-PAF C-16-d4

Cayman Chemical Item Number 360906

Lyso-Platelet-activating Factor C-16-d4

Lyso-PAF C-16-d4

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Description

Lyso-PAF C-16-d4 contains four deuterium atoms at the 7, 7', 8, and 8' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16,1 or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine.2,3 Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway4 or selective acylation with arachidonic acid by a CoA-independent transacylase.5

1 Stafforini, D.M., Prescott, S.M., and McIntyre, T.M. Human plasma platelet-activating factor acetylhydrolase. J Biol Chem 262 4223-4230 (1987).

2 Uemura, Y., Lee, T., and Snyder, F. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem 266 8268-8272 (1991).

3 Venable, M.E., Nieto, M.L., Schmitt, J.D., et al. Conversion of 1-O-[3H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils. J Biol Chem 266 18691-18698 (1991).

4 Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

5 Venable, M.E., Olson, S.C., Nieto, M.L., et al. Enzymatic studies of lyso platelet-activation factor acylation in human neutrophils and changes upon stimulation. J Biol Chem 268 7965-7975 (1993).

Synonyms
  • Lyso-Platelet-activating Factor C-16-d4
Formal Name 1-​O-​hexadecyl-​(7,​7,​8,​8-​d4)-​sn-​glyceryl-​3-​phosphorylcholine
Molecular Formula C24H48D4NO6P
Formula Weight 485.7
Formulation A solution in ethanol
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOC[C@@H]​(O)​COP(=O)​(O)​OCC[N]​(C)​(C)​C

Background Reading

Venable, M.E., Nieto, M.L., Schmitt, J.D., et al. Conversion of 1-O-[3H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils. J Biol Chem 266 18691-18698 (1991).

Venable, M.E., Olson, S.C., Nieto, M.L., et al. Enzymatic studies of lyso platelet-activation factor acylation in human neutrophils and changes upon stimulation. J Biol Chem 268 7965-7975 (1993).

Uemura, Y., Lee, T., and Snyder, F. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem 266 8268-8272 (1991).

Stafforini, D.M., Prescott, S.M., and McIntyre, T.M. Human plasma platelet-activating factor acetylhydrolase. J Biol Chem 262 4223-4230 (1987).

Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

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Size Price Quantity Subtotal
100 µg $20.00 $0.00
500 µg $90.00 $0.00
1 mg $160.00 $0.00
5 mg $700.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Lyso-PAF C-16

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