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15(S)-HETrE

Cayman Chemical Item Number 36720

(CAS 92693-02-2)

15(S)-HETrE (CAS 92693-02-2)

See more	Inhibitors (493) Lipoxygenase (84) Oxylipins (226)

Description

15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of DGLA. It is an inhibitor of 5-LO in human PMNL with an IC₅₀ value of 4.6 µM.¹ In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.²

1 Petrich, K., Ludwig, P., Kühn, H., et al. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leukocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action. Biochem J 314 911-916 (1996).

2 Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J Med Chem 30 254-263 (1987).

Formal Name	15S-hydroxy-8Z,11Z,13E-eicosatrienoic acid
CAS Number	92693-02-2
Molecular Formula	C₂₀H₃₄O₃
Formula Weight	322.5
Formulation	A solution in ethanol
Purity	≥98%
λ_max	236 nm
ε	23
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC[C@@H](O)/C=C/C=C\C/C=C\CCCCCCC(O)=O

Background Reading

Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J Med Chem 30 254-263 (1987).

Petrich, K., Ludwig, P., Kühn, H., et al. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leukocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action. Biochem J 314 911-916 (1996).

15(S)-HETrE is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$30.00		$0.00
50 µg	$57.00		$0.00
100 µg	$108.00		$0.00
500 µg	$480.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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