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15-OxoEDE

Cayman Chemical Item Number 37730

15-KEDE (CAS 105835-44-7)

15-OxoEDE (CAS 105835-44-7)

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Description

15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 µM, which is about 2-fold lower than 15(S)-HEDE.1 A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.2

1 Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J Med Chem 30 254-263 (1987).

2 Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).

Synonyms
  • 15-KEDE
Formal Name 15-​oxo-​11Z,​13E-​eicosadienoic acid
CAS Number 105835-44-7
Molecular Formula C20H34O3
Formula Weight 322.5
Formulation A solution in ethanol
Purity >95%
λmax 279 nm
ε 23
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCCC(=O)​/C=C\C=C\CCCCCCCCCC(=O)​O

Background Reading

Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).

Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J Med Chem 30 254-263 (1987).

15-OxoEDE is available in the following screening library:

Size Price Quantity Subtotal
25 µg $52.00 $0.00
50 µg $99.00 $0.00
100 µg $187.00 $0.00
250 µg $416.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

12-OxoETE
13-OxoODE
(±)15-HEDE
15-OxoETE
5-OxoETE
9-OxoODE
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