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15-OxoEDE

Cayman Chemical Item Number 37730

15-KEDE (CAS 105835-44-7)

15-OxoEDE (CAS 105835-44-7)

See more	Oxylipins (226)

Description

15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC₅₀ of 55 µM, which is about 2-fold lower than 15(S)-HEDE.¹ A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity.²

1 Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J Med Chem 30 254-263 (1987).

2 Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).

Synonyms	15-KEDE
Formal Name	15-oxo-11Z,13E-eicosadienoic acid
CAS Number	105835-44-7
Molecular Formula	C₂₀H₃₄O₃
Formula Weight	322.5
Formulation	A solution in ethanol
Purity	>95%
λ_max	279 nm
ε	23
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(=O)/C=C\C=C\CCCCCCCCCC(=O)O

Background Reading

Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).

Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J Med Chem 30 254-263 (1987).

15-OxoEDE is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$52.00		$0.00
50 µg	$99.00		$0.00
100 µg	$187.00		$0.00
250 µg	$416.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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