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9(R)-HODE

Cayman Chemical Item Number 38405

(CAS 10075-11-3)

9(R)-HODE (CAS 10075-11-3)

See more	Oxylipins (227)

Description

9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) configuration at the site of oxygen insertion. However, both human umbilical vein endothelial cells and bovine aorta endothelial cells have been shown to produce 9(R)-HODE when incubated with linoleic acid.^1,2 The physiological function of 9(R)-HODE and the enzyme that catalyzes its formation have not been determined.

1 Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells. Biochim Biophys Acta 1085 45-52 (1991).

2 Camacho, M., Godessart, N., Anton, R., et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J Biol Chem 270 17279-17286 (1995).

Formal Name	9R-hydroxy-10E,12Z-octadecadienoic acid
CAS Number	10075-11-3
Molecular Formula	C₁₈H₃₂O₃
Formula Weight	296.5
Formulation	A solution in ethanol
Purity	≥98%
λ_max	234 nm
ε	23
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C=C/C(C)CCCCCCCC(=O)O

Background Reading

Camacho, M., Godessart, N., Anton, R., et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J Biol Chem 270 17279-17286 (1995).

Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells. Biochim Biophys Acta 1085 45-52 (1991).

9(R)-HODE is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$50.00		$0.00
50 µg	$95.00		$0.00
100 µg	$180.00		$0.00
250 µg	$400.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(±)9-HODE

(±)9-HpODE Exclusive

9(S)-HODE

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