Cayman Chemical | (±)13-HODE cholesteryl ester | Description (CAS 167354-91-8)

38601 (±)13-HODE cholesteryl ester

(CAS 167354-91-8)

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• See more Oxylipins; Atherosclerosis; Oxidative Injury

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(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions¹ and shown to be produced by Cu2+-catalyzed oxidation of LDL.² Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 13-HODE cholesteryl ester.^3,4

1 Brooks, C.J.W., Harland, W.A., Steel, G., et al. Lipids of human atheroma: Isolation of hydroxyoctadecadienoic acids from advanced aortal lesions. Biochim Biophys Acta 202 563-566 (1970).

2 Lenz, M.L., Hughes, H., Mitchell, J.R., et al. Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. J Lipid Res 31 1043-1050 (1990).

3 Belkner, J., Wiesner, R., Kühn, H., et al. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Lett 279 110-114 (1991).

4 Folcik, V.A., Cathcart, M.K. Predominance of esterified hydroperoxy-linoleic acid in human monocyte-oxidized LDL. J Lipid Res 35 1570-1582 (1994).

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Pricing updated 2010-03-11.
Prices are subject to change without notice.

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