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13(R)-HODE

Cayman Chemical Item Number 38605

(CAS 10219-69-9)

13(R)-HODE (CAS 10219-69-9)

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Description

13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.1 13(R)-HODE is a weak (IC50 = 2.7 µM) inhibitor of U-46619-induced platelet aggregation.2

1 Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells. Biochim Biophys Acta 1085 45-52 (1991).

2 Lagarde, M., Boutillon, M.M., Guichardant, M., et al. Further studies on the anti-thromboxane A2 activity of monohydroxylated fatty acids. Biochem Pharmacol 38 1863-1864 (1989).

Formal Name 13R-​hydroxy-​9Z,​11E-​octadecadienoic acid
CAS Number 10219-69-9
Molecular Formula C18H32O3
Formula Weight 296.5
Formulation A solution in ethanol
Purity ≥98%
λmax 234 nm
ε 23
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@@H]​(O)​\C=C\C=C\CCCCCCCC(=O)​O

Background Reading

Lagarde, M., Boutillon, M.M., Guichardant, M., et al. Further studies on the anti-thromboxane A2 activity of monohydroxylated fatty acids. Biochem Pharmacol 38 1863-1864 (1989).

Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells. Biochim Biophys Acta 1085 45-52 (1991).

13(R)-HODE is available in the following screening library:

Size Price Quantity Subtotal
25 µg $59.00 $0.00
50 µg $112.00 $0.00
100 µg $212.00 $0.00
250 µg $472.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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9(S)-HpODE
Linoleic Acid
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