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13(R)-HODE

Cayman Chemical Item Number 38605

(CAS 10219-69-9)

13(R)-HODE (CAS 10219-69-9)

See more	Oxylipins (226)

Description

13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.¹ 13(R)-HODE is a weak (IC₅₀ = 2.7 µM) inhibitor of U-46619-induced platelet aggregation.²

1 Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells. Biochim Biophys Acta 1085 45-52 (1991).

2 Lagarde, M., Boutillon, M.M., Guichardant, M., et al. Further studies on the anti-thromboxane A₂ activity of monohydroxylated fatty acids. Biochem Pharmacol 38 1863-1864 (1989).

Formal Name	13R-hydroxy-9Z,11E-octadecadienoic acid
CAS Number	10219-69-9
Molecular Formula	C₁₈H₃₂O₃
Formula Weight	296.5
Formulation	A solution in ethanol
Purity	≥98%
λ_max	234 nm
ε	23
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC[C@@H](O)\C=C\C=C\CCCCCCCC(=O)O

Background Reading

Lagarde, M., Boutillon, M.M., Guichardant, M., et al. Further studies on the anti-thromboxane A₂ activity of monohydroxylated fatty acids. Biochem Pharmacol 38 1863-1864 (1989).

Baer, A.N., Costello, P.B., and Green, F.A. Stereospecificity of the hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids produced by cultured bovine endothelial cells. Biochim Biophys Acta 1085 45-52 (1991).

13(R)-HODE is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$59.00		$0.00
50 µg	$112.00		$0.00
100 µg	$212.00		$0.00
250 µg	$472.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(±)13-HpODE

13(S)-HODE

15-Lipoxygenase (soybean P₁) - Purified

9(S)-HODE-d₄

9(S)-HpODE

Linoleic Acid

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