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13(S)-HODE

Cayman Chemical Item Number 38610

(CAS 29623-28-7)

13(S)-HODE (CAS 29623-28-7)

See more	Inhibitors (493) Oxylipins (226)

Description

13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,^1,2 and down regulates the expression of the IRGpIIb/IIIa receptor.³

1 Buchanan, M.R., Haas, T.A., Lagarde, M., et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. J Biol Chem 260 16056-16059 (1985).

2 Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44 413-429 (1992).

3 Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res 49 1029-1037 (1989).

Formal Name	13S-hydroxy-9Z,11E-octadecadienoic acid
CAS Number	29623-28-7
Molecular Formula	C₁₈H₃₂O₃
Formula Weight	296.5
Formulation	A solution in ethanol
Purity	≥98%
λ_max	234 nm
ε	23
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O

Background Reading

Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res 49 1029-1037 (1989).

Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44 413-429 (1992).

Buchanan, M.R., Haas, T.A., Lagarde, M., et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. J Biol Chem 260 16056-16059 (1985).

13(S)-HODE is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 µg	$64.00		$0.00
500 µg	$288.00		$0.00
1 mg	$512.00		$0.00
5 mg	$2,240.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(±)13-HODE

(±)13-HpODE

13(R)-HODE

13(S)-HODE-d₄

13(S)-HODE methyl ester

13(S)-HpODE

9(S)-HODE

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