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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

13(S)-HODE-biotin

Cayman Chemical Item Number 38612

13(S)-HODE-biotin

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Description

13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.1 The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.2

1 van de Velde, M.J., Engels, F., Henricks, P.A.J., et al. 13-HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells. J Leukoc Biol 56 200-202 (1994).

2 Kang, L., and Vanderhoek, J.Y. Synthesis and use of a novel biotinylated probe for the chemiluminescent detection of proteins that bind 15-hydroxyeicosatetraenoic acid. Anal Biochem 250 119-122 (1997).

Formal Name 13S-​hydroxy-​9Z,​11E-​octadecadiene-​(2-​biotinyl)hydrazide
Molecular Formula C28H48N4O4S
Formula Weight 536.8
Formulation A solution in ethanol
Purity ≥98% (may contain trace amounts of free biotin)
λmax 234 nm
ε 30
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​\C=C\C=C\CCCCCCCC(=O)​NNC(=O)​CCCC[C@H]​1SC[C@@H]​2NC(=O)​N[C@H]​12

Background Reading

Kang, L., and Vanderhoek, J.Y. Synthesis and use of a novel biotinylated probe for the chemiluminescent detection of proteins that bind 15-hydroxyeicosatetraenoic acid. Anal Biochem 250 119-122 (1997).

van de Velde, M.J., Engels, F., Henricks, P.A.J., et al. 13-HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells. J Leukoc Biol 56 200-202 (1994).
Size Price Quantity Subtotal
100 µg $100.00 $0.00
500 µg $450.00 $0.00
1 mg $800.00 $0.00
5 mg $3,500.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

13(S)-HODE
13(S)-HODE methyl ester
15(S)-HETE-biotin

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