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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Arachidonic Acid-d8

Cayman Chemical Item Number 390010

(CAS 69254-37-1)

Arachidonic Acid-d8 (CAS 69254-37-1)

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Description

Arachidonic acid-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of arachidonic acid by GC- or LC-mass spectrometry. Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways.1 Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-update of free arachidonate are all important aspects of cell signaling and inflammation.2

1 Burgoyne, R.D., and Morgan, A. The control of free arachidonic acid levels. Trends Biochem Sci 15 365-366 (1990).

2 Nixon, A.B., Greene, D.G., and Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. Biochim Biophys Acta 1300 187-196 (1996).

Formal Name 5Z,​8Z,​11Z,​14Z-​eicosatetraenoic-​5,​6,​8,​9,​11,​12,​14,​15-​d8 acid
CAS Number 69254-37-1
Molecular Formula C20H24D8O2
Formula Weight 312.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​O

Background Reading

Burgoyne, R.D., and Morgan, A. The control of free arachidonic acid levels. Trends Biochem Sci 15 365-366 (1990).

Nixon, A.B., Greene, D.G., and Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. Biochim Biophys Acta 1300 187-196 (1996).

Size Price Quantity Subtotal
1 mg $87.00 $0.00
5 mg $392.00 $0.00
10 mg $696.00 $0.00
50 mg $3,045.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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