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Arachidonic Acid methyl ester-d8 Exclusive

Cayman Chemical Item Number 390014

Methyl Arachidonate-d8

Arachidonic Acid methyl ester-d8

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Description

Arachidonic acid is the keystone essential fatty acid at the origin of the arachidonic acid cascade. It is converted by cyclooxygenase, lipoxygenase, and epoxygenase enzymes into more than one hundred fifty different potent primary autacoid metabolites in species ranging from fungi to plants to mammals. Arachidonic acid is stored in tissue phospholipids in esterified form, where it comprises a small but critically controlled percentage of the polyunsaturated fatty acid pool.1 Arachidonic acid content is frequently measured by the saponification of the lipid fraction followed by methyl esterification and gas chromatographic analysis of the resulting FAME (fatty acid methyl ester) compounds.2,3 Arachidonic acid methyl ester can also be incorporated into dietary regimens or fed to cultured cells as a source of exogenous arachidonate.

1 Holman, R.T. Control of polyunsaturated acids in tissue lipids. J Am Coll Cardiol 5 183-211 (1986).

2 Leichsenring, M., Sütterlin, N., Less, S., et al. Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. Acta Paediatr 84 516-520 (1995).

3 Burdge, G.C., and Postle, A.D. Phospholipid molecular species composition of developing fetal guinea pig brain. Lipids 30 719-724 (1995).

Synonyms
  • Methyl Arachidonate-d8
Molecular Formula C21H36D8O2
Formula Weight 326.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d8)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC\C([2H]​)​=C([2H]​)​/C\C([2H]​)​=C([2H]​)​/C/C([2H]​)​=C([2H]​)​\C/C([2H]​)​=C([2H]​)​\CCCC(OC)​=O

Background Reading

Burdge, G.C., and Postle, A.D. Phospholipid molecular species composition of developing fetal guinea pig brain. Lipids 30 719-724 (1995).

Leichsenring, M., Sütterlin, N., Less, S., et al. Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. Acta Paediatr 84 516-520 (1995).

Holman, R.T. Control of polyunsaturated acids in tissue lipids. J Am Coll Cardiol 5 183-211 (1986).
Size Price Quantity Subtotal
500 µg $54.00 $0.00
1 mg $103.00 $0.00
5 mg $432.00 $0.00
10 mg $756.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Arachidonic Acid ethyl ester
Arachidonic Acid methyl ester
Arachidonic Acid (peroxide free)
Arachidonic Acid (sodium salt)
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Batch-specific Information

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FAQs

It appears that there is a heterogenous mixture of deuterated species in your deuterated standards; is this normal?

Yes, this is typical of our deuterated products. Our deuterated products contain less than 1 % d0. However, the labeled compounds are not 100% of the deuterated form listed on our product insert. For example, upon analysis of 2-arachidonoyl glycerol-d8 it is expected to see masses associated with the d7, d6, d5 etc.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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