Arachidonic Acid methyl ester-d8

Arachidonic Acid methyl ester-d₈ Exclusive

Cayman Chemical Item Number 390014

Methyl Arachidonate-d₈

Description

Arachidonic acid is the keystone essential fatty acid at the origin of the arachidonic acid cascade. It is converted by cyclooxygenase, lipoxygenase, and epoxygenase enzymes into more than one hundred fifty different potent primary autacoid metabolites in species ranging from fungi to plants to mammals. Arachidonic acid is stored in tissue phospholipids in esterified form, where it comprises a small but critically controlled percentage of the polyunsaturated fatty acid pool.¹ Arachidonic acid content is frequently measured by the saponification of the lipid fraction followed by methyl esterification and gas chromatographic analysis of the resulting FAME (fatty acid methyl ester) compounds.^2,3 Arachidonic acid methyl ester can also be incorporated into dietary regimens or fed to cultured cells as a source of exogenous arachidonate.

1 Holman, R.T. Control of polyunsaturated acids in tissue lipids. J Am Coll Cardiol 5 183-211 (1986).

2 Leichsenring, M., Sütterlin, N., Less, S., et al. Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. Acta Paediatr 84 516-520 (1995).

3 Burdge, G.C., and Postle, A.D. Phospholipid molecular species composition of developing fetal guinea pig brain. Lipids 30 719-724 (1995).

Synonyms

Methyl Arachidonate-d8

Molecular Formula

C₂₁H₃₆D₈O₂

Formula Weight

326.5

Formulation

A solution in methyl acetate

Purity

≥99% deuterated product

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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CCCCC\C([2H])=C([2H])/C\C([2H])=C([2H])/C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCC(OC)=O

Background Reading

Leichsenring, M., Sütterlin, N., Less, S., et al. Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. Acta Paediatr 84 516-520 (1995).

Holman, R.T. Control of polyunsaturated acids in tissue lipids. J Am Coll Cardiol 5 183-211 (1986).

Burdge, G.C., and Postle, A.D. Phospholipid molecular species composition of developing fetal guinea pig brain. Lipids 30 719-724 (1995).

Size

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Quantity

Subtotal

500 µg 
$54.00

$0.00

1 mg 
$103.00

$0.00

5 mg 
$432.00

$0.00

10 mg 
$756.00

$0.00

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$0.00

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Arachidonic Acid methyl ester-d₈ Exclusive