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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Arachidonoyl Ethanolamide-d8

Cayman Chemical Item Number 390050

Anandamide-d8; AEA-d8

Arachidonoyl Ethanolamide-d8

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Description

Arachidonoyl ethanolamide-d8 (AEA-8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of AEA by GC- or LC-mass spectrometry. AEA is the ethanolamine amide of arachidonic acid, first isolated from porcine brain.1 It is an endogenous cannabinoid neurotransmitter that binds to both CB1 and CB2 receptors.2 AEA inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM, compared to 46 nM for Δ9-THC.1

1 Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

2 Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 90 7656-7660 (1993).

Synonyms
  • Anandamide-d8
  • AEA-d8
Formal Name N-​(2-​hydroxyethyl)-​5Z,​8Z,​11Z,​14Z-​eicosatetraenamide-​5,​6,​8,​9,​11,​12,​14,​15-​d8
Molecular Formula C22H29D8NO2
Formula Weight 355.6
Formulation A solution in methyl acetate
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​NCCO

Background Reading

Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 90 7656-7660 (1993).

Size Price Quantity Subtotal
100 µg $38.00 $0.00
500 µg $171.00 $0.00
1 mg $304.00 $0.00
5 mg $1,330.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Arachidonoyl Ethanolamide
Arachidonoyl Glycine-d8

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Batch-specific Information

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FAQs

On the product insert for Arachidonoyl Ethanolamide-d8 it states the chemical purity is 97% and contains no d0 (undeuterated compound). Are there other deuterated forms present?

In our catalog we state that the Arachidonoyl Ethanolamide-d8 is less than or equal to 1% of the undeuterated compound. There can be other deuterated forms. We can assure you that the compound does have less than 1% of the undeuterated compound present.

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