500581  Prostaglandin D2 FPIA Kit - Green

PGD2 Fluorescence Polarization Immunoassay - Green

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• See more Fluorescence Polarization; Assay Kits; Prostaglandins; Allergy/Asthma; Drug Discovery

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Limit of detection: 470 pg/ml · Prostaglandin D2 (PGD2) is biosynthesized in the brain by a glutathione-independent lipocalin-type PGD2 synthase (L-PGDS).1 It accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans.2 PGD2 is also synthesized by mast cells and leukocytes by a cellular, myeloid-type, glutathione-dependent PGD synthase (hematopoietic PGD Synthase; H-PGDS).3 In this setting, PGD2 and acts as a pro-inflammatory mediator in allergic reactions following release in large amounts from allergen-stimulated mast cells. Cayman’s PGD2 Fluorescence Polarization Immunoassay (FPIA) is especially designed for High Throughput Screening (HTS) applications for direct, rapid measurement of PGD2. The assay is particularly suited for samples from cell culture and purified enzyme preparations. The PGD2-FPIA is robust (Z' = 0.74), exhibits D120 mP over a range of 244 pg/ml to 1,000 ng/ml PGD2, and has a detection limit of 470 pg/ml.
1  Urade, Y., Tanaka, T., Eguchi, N., et al. Structural and functional significance of cysteine residues of glutathione-independent prostaglandin D synthase. J Biol Chem 270 1422-1428 (1995).
2  Satoh, S., Matsumura, H., Nakajima, T., et al. Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. Neurosci Res 21 41-50 (1995).
3  Kanaoka, Y., Ago, H., Inagaki, E., et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell 90 1085-1095 (1997).


Purchase 500581 Prostaglandin D2 FPIA Kit - Green

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

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