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(±)11(12)-EET

Cayman Chemical Item Number 50511

(±)11(12)-EpETrE (CAS 123931-40-8)

(±)11(12)-EET (CAS 123931-40-8)

See more	Oxylipins (226) Cytochrome P450 (88)

Description

(±)11(12)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.^1,2 (±)11(12)-EET has been shown, along with (±)8(9)-EET, to play a role in the recovery of depleted Ca2+ pools in cultured smooth muscle cells.³

1 Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).

2 Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

3 Graber, M.N., Alfonso, A., and Gill, D.L. Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. J Biol Chem 272 29546-29553 (1997).

Synonyms	(±)11(12)-EpETrE
Formal Name	(±)11(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid
CAS Number	123931-40-8
Molecular Formula	C₂₀H₃₂O₃
Formula Weight	320.5
Formulation	A solution in ethanol
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(=O)O

Background Reading

Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).

Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

Graber, M.N., Alfonso, A., and Gill, D.L. Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. J Biol Chem 272 29546-29553 (1997).

(±)11(12)-EET is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$36.00		$0.00
50 µg	$65.00		$0.00
100 µg	$115.00		$0.00
500 µg	$360.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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(±)8(9)-EET

S-NEPC Exclusive

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