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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)14(15)-EET methyl ester

Cayman Chemical Item Number 50650

(±)14(15)-EpETrE methyl ester

(±)14(15)-EET methyl ester

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Description

(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.1,2 Dramatic increases in urinary (±)14,15-DiHETrE, a (±)14(15)-EET metabolite, have been documented by GC/MS in pregnancy induced hypertension.3 (±)14(15)-EET methyl ester is a more stable form used for long-term storage. It can be readily hydrolyzed to the free acid as needed.

1 Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).

2 Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

3 Catella, F., Lawson, J.A., Fitzgerald, D.J., et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proc Natl Acad Sci USA 87 5893-5897 (1990).

Synonyms
  • (±)14(15)-EpETrE methyl ester
Formal Name (±)14(15)-​epoxy-​5Z,​8Z,​11Z-​eicosatrienoic acid,​ methyl ester
Molecular Formula C21H34O3
Formula Weight 334.5
Formulation A solution in ethanol
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​1O[C@H]​1C/C=C\C/C=C\C/C=C\CCCC(=O)​OC

Background Reading

Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).

Catella, F., Lawson, J.A., Fitzgerald, D.J., et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proc Natl Acad Sci USA 87 5893-5897 (1990).
Size Price Quantity Subtotal
25 µg $54.00 $0.00
50 µg $103.00 $0.00
100 µg $194.00 $0.00
250 µg $432.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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