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(±)5,6-DHET

Cayman Chemical Item Number 51211

(±)5,6-DiHETrE (CAS 213382-49-1)

(±)5,6-DHET (CAS 213382-49-1)

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Description

Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 (±)5,(6)-DHET is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F metabolites in vitro.2

1 Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

2 Oliw, E.H. Biosynthesis of 5,6-dihydroxyprostaglandin E1 and F from 5,6-dihydroxyeicosatrienoic acid by ram seminal vesicles. Biochim Biophys Acta 795 384-391 (1984).

Synonyms
  • (±)5,6-DiHETrE
Formal Name (±)5,​6-​dihydroxy-​8Z,​11Z,​14Z-​eicosatrienoic acid
CAS Number 213382-49-1
Molecular Formula C20H34O4
Formula Weight 338.5
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C[C@@H]​(O)​[C@@H]​(O)​CCCC(O)​=O

Background Reading

Oliw, E.H. Biosynthesis of 5,6-dihydroxyprostaglandin E1 and F from 5,6-dihydroxyeicosatrienoic acid by ram seminal vesicles. Biochim Biophys Acta 795 384-391 (1984).

Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

(±)5,6-DHET is available in the following screening library:

Size Price Quantity Subtotal
25 µg $74.00 $0.00
50 µg $141.00 $0.00
100 µg $266.00 $0.00
250 µg $592.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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