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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)11,12-DHET

Cayman Chemical Item Number 51511

(±)11,12-DiHETrE

(±)11,12-DHET

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Description

Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 11,12-DHET relaxes U-46619-contracted artery rings with approximately 70% of the magnitude of 11,12-EET.2

1 Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

2 Fang, X., Kaduce, T.L., Weintraub, N.L., et al. Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle. Circ Res 79 784-793 (1996).

Synonyms
  • (±)11,12-DiHETrE
Formal Name (±)11,​12-​dihydroxy-​5Z,​8Z,​14Z-​eicosatrienoic acid
Molecular Formula C20H34O4
Formula Weight 338.5
Formulation A solution in ethanol
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C[C@@H]​(O)​[C@@H]​(O)​C/C=C\C/C=C\CCCC(=O)​O

Background Reading

Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

Fang, X., Kaduce, T.L., Weintraub, N.L., et al. Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle. Circ Res 79 784-793 (1996).

(±)11,12-DHET is available in the following screening library:

Size Price Quantity Subtotal
25 µg $74.00 $0.00
50 µg $141.00 $0.00
100 µg $266.00 $0.00
250 µg $592.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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