Estriol EIA Kit

Estriol EIA Kit

Cayman Chemical Item Number 582281

Estriol ELISA Kit

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Pre-configured for analysis on MyAssays.com

Description

Limit of detection: 80% B/B₀: 4 pg/ml (4°C for 18 hours) 14 pg/ml (RT for 2 hours) · Sensitivity: 50% B/B₀: 33 pg/ml (4°C for 18 hours) 95 pg/ml (RT for 2 hours) · Estriol, a metabolite of 17β-estradiol and a major estrogen produced during pregnancy, has historically been used as an indicator of fetal well-being. In the final weeks before parturition, estriol levels increase significantly. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38.¹ The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate (DHEAS) and serves as a direct marker of fetal adrenal gland activity.² In the 1960s and 1970s plasma and urine were used to measure estriol. However, saliva contains primarily unbound and unconjugated estriol, the biologically active form of the hormone, and therefore is currently a commonly used biological fluid for monitoring estriol levels.^2,3 Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.⁴

1 Peter, M., Dörr, H.G., and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Horm Res 42 278-281 (1994).

2 Goodwin, T.M. A role for estriol in human labor, term and preterm. Am J Obstet Gynecol 180 S208-S213 (1999).

3 Voss, H.F. Hormonal pathways of preterm birth. Am J Obstet Gynecol 180 S226-S231 (1999).

4 . Steroid levels in humans. (1999 Apr 19).

Synonyms

Estriol ELISA Kit

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Estriol	100%
Estriol-3-glucuronide	6%
Estriol-16-glucuronide	1.2%
Estradiol	0.6%
Estrone	0.02%
11-deoxy Corticosterone	<0.01%
DHEA	<0.01%
Ethinyl estradiol	<0.01%
Progesterone	<0.01%
Testosterone	<0.01%
5α-dihydro Testosterone	<0.01%

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Background Reading

Peter, M., Dörr, H.G., and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Horm Res 42 278-281 (1994).

Pradelles, P., Grassi, J., and Maclouf, J.A. Enzyme immunoassays of eicosanoids using acetylcholinesterase as label: An alternative to radioimmunoassay. Anal Chem 57 1170-1173 (1985).

Maxey, K.M., Maddipati, K.R., and Birkmeier, J. Interference in enzyme immunoassays. J Clin Immunoassay 15 116-120 (1992).

Maclouf, J., Grassi, J., and Pradelles, P. Development of enzyme-immunoassay techniques for the measurement of eicosanoids. 355-364 (1987).

Goodwin, T.M. A role for estriol in human labor, term and preterm. Am J Obstet Gynecol 180 S208-S213 (1999).

Voss, H.F. Hormonal pathways of preterm birth. Am J Obstet Gynecol 180 S226-S231 (1999).

. Steroid levels in humans. (1999 Apr 19).

Show all 7 Hide all but first 3

582281-96WELL

Estriol EIA Kit

Estriol EIA Kit

Estriol EIA Kit Analysis Tools

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