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Myeloperoxidase (human) EIA Kit

Cayman Chemical Item Number 585001

MPO (human) EIA Kit

Myeloperoxidase (human) EIA Kit

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Description

Limit of detection: 14 pmol/L · The activation of leukocytes prompts the secretion of myeloperoxidase (MPO) and the generation of oxidants.1 Several lines of evidence suggest that MPO secreted by leukocytes participates in atherosclerotic progression and contributes to plaque vulnerability.2,3 MPO has been linked to the development of lipid-laden soft plaque, the activation of protease cascades affecting the stability and thrombogenicity of plaque, the production of cytotoxic and prothrombogenic oxidized lipids, and the consumption of nitric oxide, leading to vasoconstriction.3 The plasma MPO concentration in patient samples acquired during the period of assessment for acute coronary syndrome in emergency departments predicts the risk of major adverse cardiac events: i.e., myocardial infarction, need for revascularization or death, over the next 30-day and 6-month interval.2 The odds ratio for adverse cardiac events increases with increasing levels of plasma MPO in all quartiles of the population. The predictive power of the MPO concentration is independent of age, gender, race, CRP level, Troponin T level, CK-MB level, history of diabetes, history of smoking, history of hyperlipidemia, or history of hypertension. Cayman’s MPO (human) EIA Kit is an immunometric assay which can be used to measure MPO in plasma without prior sample purification. This assay has been tested using plasma from healthy volunteers and the results shown to be consistent with published data. The standard curve spans the range of approximately 0-8,000 pmol/L. The minimum detection limit, as calculated by interpolation of the mean plus two standard deviations of 26 replicates of the 0 pmol/L MPO Standard, is 14 pmol/L.

1 Klebanoff, S.J., Waltersdorph, A.M., and Rosen, H. Antimicrobial activity of myeloperoxidase. Methods Enzymol 105 399-403 (1984).

2 Brennan, M., Penn, M.S., Van Lente, F., et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 349(17) 1595-1604 (2003).

3 Hazen, S.L. Myeloperoxidase and plaque vulnerability. Arterioscler Thromb Vasc Biol 24 1143-1146 (2004).

Synonyms
  • MPO (human) EIA Kit
Stability 6 months
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

CLSI (formerly NCCLS). CLSI Document. H18-A2 (1999).

Horn, P.S., Feng, L., Li, Y., et al. Effect of outliers and nonhealthy individuals on reference interval estimation. Clin Chem 47(12) 2137-2145 (2001).

McErlean, E.S., Deluca, S.A., Van Lente, F., et al. Comparison of troponin T versus creatine kinase-MB in suspected acute coronary syndromes. Am J Cardiol 85 421-426 (2000).

Klebanoff, S.J., Waltersdorph, A.M., and Rosen, H. Antimicrobial activity of myeloperoxidase. Methods Enzymol 105 399-403 (1984).

Brennan, M., Penn, M.S., Van Lente, F., et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 349(17) 1595-1604 (2003).

Hazen, S.L. Myeloperoxidase and plaque vulnerability. Arterioscler Thromb Vasc Biol 24 1143-1146 (2004).

Engvall, E., and Pearlmann, P. Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G. Immunochemistry 8 871-874 (1971).

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Size Price Quantity Subtotal
96 wells $686.00 $0.00
Bulk Contact
Cart Total $0.00

This product is also available to buy in bulk quantities.

Please contact our Sales Department for a quote or to purchase.

  • Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

You may be eligible to receive a free sample Myeloperoxidase (human) EIA Kit under the Cayman Challenge program.

Let Cayman analyze your samples for you. See EIA Service for details and availability.

Related Products

MPO (human) Control Set
MPO (human) EIA Standards
Myeloperoxidase Chlorination Assay Kit
Myeloperoxidase Inhibitor Screening Assay Kit
Myeloperoxidase Peroxidation Assay Kit
UltraPure Water
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