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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

p53 Cell-Based Activation/Translocation Assay Kit

Cayman Chemical Item Number 600008

p53 Cell-Based Activation/Translocation Assay Kit

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Description

The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman’s p53 Cell-Based Activation/Translocation Assay Kit provides a highly specific p53 primary monoclonal antibody together with a DyLight™ (product of Thermo Fisher Scientific Inc.) conjugated secondary antibody in a ready-to-use format. (−)-Nutlin-3, a potent inhibitor of Mdm2-p53 interaction, which has been shown by scientists at Cayman to cause the activation and translocation of p53 between the cytoplasm and nuclear compartments, is included as a positive control.
Stability 6 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Brooks, C.L., and Gu, W. p53 ubiquitination: Mdm2 and beyond. Mol Cell 21 307-315 (2006).

Haupt, S., Berger, M., Goldberg, Z., et al. Apoptosis-the p53 network. J Cell Sci 116 4077-4085 (2003).

Gasco, M., Shami, S., and Crook, T. The p53 pathway in breast cancer. Breast Cancer Res 4 70-76 (2002).

Liang, S., and Clarke, M.F. Regulation of p53 localization. Eur J Biochem 268 2779-2783 (2001).

Dey, A., Verma, C.S., and Lane, D.P. Updates on p53: Modulation of p53 degradation as a therapeutic approach. Br J Cancer 98 4-8 (2008).

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600008-96well
Cell-Based Assay Fixative 1 ea
Cell-Based Assay Blocking Solution 1 ea
Cell-Based Assay (-)-Nutlin-3 (10 mM) 1 ea
Cell-Based Assay p53 Total Monoclonal Primary Antibody 1 ea
DyLightTM 549-Conjugated Goat Anti-Mouse IgG Secondary Antibody 1 ea
Size Price Quantity Subtotal
96 wells $198.00 $0.00
Bulk Contact
Cart Total $0.00

This product is also available to buy in bulk quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

You may be eligible to receive a free sample p53 Cell-Based Activation/Translocation Assay Kit under the Cayman Challenge program.

Let Cayman analyze your samples for you. See EIA Service for details and availability.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

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