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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

p53 Cell-Based Activation/Translocation Assay Kit

Cayman Chemical Item Number 600008

p53 Cell-Based Activation/Translocation Assay Kit

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Description

The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman’s p53 Cell-Based Activation/Translocation Assay Kit provides a highly specific p53 primary monoclonal antibody together with a DyLight™ (product of Pierce Biotechnology, Inc.) conjugated secondary antibody in a ready-to-use format. (−)-Nutlin-3, a potent inhibitor of Mdm2-p53 interaction, which has been shown by scientists at Cayman to cause the activation and translocation of p53 between the cytoplasm and nuclear compartments, is included as a positive control.
Stability 6 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Brooks, C.L., and Gu, W. p53 ubiquitination: Mdm2 and beyond. Mol Cell 21 307-315 (2006).

Haupt, S., Berger, M., Goldberg, Z., et al. Apoptosis-the p53 network. J Cell Sci 116 4077-4085 (2003).

Gasco, M., Shami, S., and Crook, T. The p53 pathway in breast cancer. Breast Cancer Res 4 70-76 (2002).

Liang, S., and Clarke, M.F. Regulation of p53 localization. Eur J Biochem 268 2779-2783 (2001).

Dey, A., Verma, C.S., and Lane, D.P. Updates on p53: Modulation of p53 degradation as a therapeutic approach. Br J Cancer 98 4-8 (2008).

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600008-96well
Cell-Based Assay Fixative 1 ea
Cell-Based Assay Blocking Solution 1 ea
Cell-Based Assay (-)-Nutlin-3 (10 mM) 1 ea
Cell-Based Assay p53 Total Monoclonal Primary Antibody 1 ea
DyLightTM 549-Conjugated Goat Anti-Mouse IgG Secondary Antibody 1 ea
Size Price Quantity Subtotal
96 wells $198.00 $0.00
Bulk Contact
Cart Total $0.00

This product is also available to buy in bulk quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

You may be eligible to receive a free sample p53 Cell-Based Activation/Translocation Assay Kit under the Cayman Challenge program.

Let Cayman analyze your samples for you. See EIA Service for details and availability.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

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