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Melanocortin-3 Receptor STEP Reporter Assay Kit (Luminescence) Exclusive

Cayman Chemical Item Number 600180

MC3R

Melanocortin-3 Receptor STEP Reporter Assay Kit (Luminescence)

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Description

The Melanocortin-3 receptor (MC3R) helps regulate energy homeostasis and mice lacking MC3R have increased fat mass and reduced lean mass. Therefore, agonists that selectively activate MC3R might have beneficial effects related to weight gain and glucose metabolism. This assay consists of a 96-well plate coated with both MC3R and Secretory Alkaline Phosphatase (SEAP) reporter constructs. Cells grown on the STEP complex will express MC3R at the cell surface. Binding of agonists to MC3R initiates a signaling cascade resulting in expression of SEAP. SEAP activity is measured following addition of luminescence-based alkaline phosphatase substrate provided in the kit.
Synonyms
  • MC3R
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Chen, A.S., Marsh, D.J., Trumbauer, M.E., et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26 97-102 (2000).

Butler, A.A., Kesterson, R.A., Khong, K., et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141(9) 3518-3521 (2000).

Ni, X., Pearce, D., Butler, A.A., et al. Genetic disruption of γ-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest 111(8) 1251-1258 (2003).

Sutton, G.M., Trevaskis, J.L., Hulver, M.W., et al. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147(5) 2183-2196 (2006).

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600180-1ea
96-Well Solid Plate (black) with lid
Melanocortin-3 Receptor STEP Strip Plate
Melanocortin Assay α-MSH Positive Control 0.01 mL
SEAP Substrate (Luminescence) 15 mL
Size Price Quantity Subtotal
100 tests $400.00 $0.00
Bulk Contact
Cart Total $0.00

This product is also available to buy in bulk quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

You may be eligible to receive a free sample Melanocortin-3 Receptor STEP Reporter Assay Kit (Luminescence) under the Cayman Challenge program.

Let Cayman analyze your samples for you. See EIA Service for details and availability.

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