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Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

COX-1 (ovine)

Cayman Chemical Item Number 60100

Prostaglandin H Synthase 1; Prostaglandin Endoperoxide Synthase; Cyclooxygenase 1

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Description

Mr: 70 kDa · Specific activity: >40,000 units/mg · Enzyme Commission (EC): 1.14.99.1 · Isolated from ram seminal vesicles · One unit of enzyme consumes one nmol of oxygen per minute at 37°C in 0.1 M Tris-HCl buffer, pH 8.0, containing 100 µM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 µM hematin.1,2,3,4

1 Smith, W.L., and Marnett, L.J. Prostaglandin endoperoxide synthase: Structure and catalysis. Biochim Biophys Acta 1083 1-17 (1991).

2 Marnett, L.J., and Maddipati, K.R. Prostaglandin H synthase. 293-334 (1991).

3 DeWitt, D.L. Prostaglandin endoperoxide synthase: Regulation of enzyme expression. Biochim Biophys Acta 1083 121-134 (1991).

4 Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

Synonyms
  • Prostaglandin H Synthase 1
  • Prostaglandin Endoperoxide Synthase
  • Cyclooxygenase 1
Formulation A solution in 80 mM Tris-HCl, pH 8.0, containing 0.1% polysorbate 20 and 300 µM DDC
Purity ≥95%
Stability 2 years
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

DeWitt, D.L. Prostaglandin endoperoxide synthase: Regulation of enzyme expression. Biochim Biophys Acta 1083 121-134 (1991).

Marnett, L.J., and Maddipati, K.R. Prostaglandin H synthase. 293-334 (1991).

Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324 26-34 (1995).

Smith, W.L., and Marnett, L.J. Prostaglandin endoperoxide synthase: Structure and catalysis. Biochim Biophys Acta 1083 1-17 (1991).

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Size Price Quantity Subtotal
5 Kunits $170.00 $0.00
10 Kunits $323.00 $0.00
50 Kunits $1,360.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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