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2-O-methyl PAF C-16

Cayman Chemical Item Number 60902

(CAS 78858-44-3)

2-O-methyl PAF C-16 (CAS 78858-44-3)

See more	Lipids (167) Phospholipase (79)

Description

2-O-methyl PAF C-16 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. Although the biological activities of 2-O-methyl PAF C-16 have not been well characterized, the C-18 analog has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.¹ In rat astrocytes, the C-18 analog causes the release of large quantities of NO by a pathway involving activation of NOS.²

1 van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22 820-823 (1987).

2 Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Res 715 98-103 (1996).

Formal Name	1-O-hexadecyl-2-O-methyl-sn-glyceryl-3-phosphorylcholine
CAS Number	78858-44-3
Molecular Formula	C₂₅H₅₄NO₆P
Formula Weight	495.7
Formulation	A lyophilized powder
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCOCC(OC)COP(=O)(O)OCC[N](C)(C)C

Background Reading

Lai, C., Joseph, J., and Shih, C.C. Molecular dynamics of antitumor ether-linked phospholipids in model membranes: A spin-label study. Biochem Biophys Res Commun 160 1189-1195 (1989).

van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22 820-823 (1987).

Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Res 715 98-103 (1996).

2-O-methyl PAF C-16 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$46.00		$0.00
10 mg	$87.00		$0.00
50 mg	$368.00		$0.00
100 mg	$644.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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PAF C-16

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