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Hexanolamino PAF C-16

Cayman Chemical Item Number 60905

(CAS 137566-83-7)

Hexanolamino PAF C-16 (CAS 137566-83-7)

See more	Lipids (167) Phospholipase (79)

Description

Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16.¹ On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a partial agonist, and in guinea pig platelets it is a full agonist.²

1 Rouis, M., Nigon, F., and Chapman, M.J. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun 156 1293-1301 (1988).

2 Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

Formal Name	1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl(N,N,N-trimethyl)hexanolamine
CAS Number	137566-83-7
Molecular Formula	C₃₀H₆₂NO₇P
Formula Weight	579.8
Formulation	A lyophilized powder
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OCCCCCC[N](C)(C)C)OC(=O)C

Background Reading

Rouis, M., Nigon, F., and Chapman, M.J. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun 156 1293-1301 (1988).

Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

Hexanolamino PAF C-16 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$21.00		$0.00
5 mg	$95.00		$0.00
10 mg	$168.00		$0.00
50 mg	$735.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

PAF C-16

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