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Lyso-PAF C-16

Cayman Chemical Item Number 60906

(CAS 52691-62-0)

Lyso-PAF C-16 (CAS 52691-62-0)

See more	Lipids (167) Phospholipase (79)

Description

Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16,¹ or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine.^2,3 Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway⁴ or selective acylation with arachidonic acid by a CoA-independent transacylase.⁵

1 Stafforini, D.M., Prescott, S.M., and McIntyre, T.M. Human plasma platelet-activating factor acetylhydrolase. J Biol Chem 262 4223-4230 (1987).

2 Uemura, Y., Lee, T., and Snyder, F. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem 266 8268-8272 (1991).

3 Venable, M.E., Nieto, M.L., Schmitt, J.D., et al. Conversion of 1-O-[³H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils. J Biol Chem 266 18691-18698 (1991).

4 Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

5 Venable, M.E., Olson, S.C., Nieto, M.L., et al. Enzymatic studies of lyso platelet-activation factor acylation in human neutrophils and changes upon stimulation. J Biol Chem 268 7965-7975 (1993).

Formal Name	1-O-hexadecyl-sn-glyceryl-3-phosphorylcholine
CAS Number	52691-62-0
Molecular Formula	C₂₄H₅₂NO₆P
Formula Weight	481.7
Formulation	A lyophilized powder
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCOC[C@@H](O)COP(=O)(O)OCC[N](C)(C)C

Background Reading

Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

Uemura, Y., Lee, T., and Snyder, F. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem 266 8268-8272 (1991).

Venable, M.E., Nieto, M.L., Schmitt, J.D., et al. Conversion of 1-O-[³H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils. J Biol Chem 266 18691-18698 (1991).

Stafforini, D.M., Prescott, S.M., and McIntyre, T.M. Human plasma platelet-activating factor acetylhydrolase. J Biol Chem 262 4223-4230 (1987).

Venable, M.E., Olson, S.C., Nieto, M.L., et al. Enzymatic studies of lyso platelet-activation factor acylation in human neutrophils and changes upon stimulation. J Biol Chem 268 7965-7975 (1993).

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Lyso-PAF C-16 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$38.00		$0.00
10 mg	$68.00		$0.00
50 mg	$228.00		$0.00
100 mg	$380.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Related Products

Lyso-PAF C-16-d₄

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