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2-O-methyl PAF C-18

Cayman Chemical Item Number 60912

Edelfosine; ET-18-OCH3; 1-O-octadecyl-2-O-methyl-sn-glyceryl-3-phosphorylcholine (CAS 77286-66-9)

2-O-methyl PAF C-18 (CAS 77286-66-9)

See more	Lipids (167) Phospholipase (79)

Description

2-O-methyl-PAF C-18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.¹ In rat astrocytes, 2-O-methyl PAF C-18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.²

1 van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22 820-823 (1987).

2 Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Res 715 98-103 (1996).

Synonyms	Edelfosine ET-18-OCH3 1-O-octadecyl-2-O-methyl-sn-glyceryl-3-phosphorylcholine
Formal Name	3,5,9-trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7R-methoxy-N,N,N-trimethyl-4-oxide
CAS Number	77286-66-9
Molecular Formula	C₂₇H₅₈NO₆P
Formula Weight	523.7
Formulation	A lyophilized powder
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCCCOCC(OC)COP(=O)(O)OCC[N](C)(C)C

Background Reading

van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22 820-823 (1987).

Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Res 715 98-103 (1996).

2-O-methyl PAF C-18 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$40.00		$0.00
10 mg	$76.00		$0.00
50 mg	$320.00		$0.00
100 mg	$560.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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PAF C-18 -d₄ Exclusive

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