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2-O-ethyl PAF C-16

Cayman Chemical Item Number 60925

2-O-ethyl PAF C-16

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Description

2-O-ethyl PAF C-16 is a synthetic PAF analog which contains an ethyl group, attached by an ether linkage, at the sn-2 position. It is a less potent agonist than methylcarbamyl PAF C-16 in the induction of platelet aggregation in both human and rabbit PRP.1 2-O-ethyl PAF C-16 causes aggregation of neutrophils in the presence of divalent cations and a desensitization to aggregation in the absence of divalent cations.2

1 Hadváry, P., Cassal, J., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23 57-64 (1983).

2 O'Flaherty, J.T., Lees, C.J., Miller, C.H., et al. Selective desensitization of neutrophils: Further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues. J Immunol 127 731-737 (1981).

Formal Name 1-​O-​hexadecyl-​2-​O-​ethyl-​sn-​glyceryl-​3-​phosphorylcholine
Molecular Formula C26H56NO6P
Formula Weight 509.7
Formulation A lyophilized powder
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOCC(OCC)​COP(=O)​(O)​OCC[N]​(C)​(C)​C

Background Reading

Hadváry, P., Cassal, J., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23 57-64 (1983).

O'Flaherty, J.T., Lees, C.J., Miller, C.H., et al. Selective desensitization of neutrophils: Further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues. J Immunol 127 731-737 (1981).

2-O-ethyl PAF C-16 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $77.00 $0.00
10 mg $146.00 $0.00
50 mg $616.00 $0.00
100 mg $1,078.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Methylcarbamyl PAF C-16
PAF C-16

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