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2-thio-PAF

Cayman Chemical Item Number 60945

(CAS 96801-55-7)

2-thio-PAF (CAS 96801-55-7)

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Description

2-thio PAF is an isosteric analog of PAF. It is also a synthetic analog of PAF which contains an acetyl group attached by a thioester bond at the sn-2 position. It functions as a PAF receptor agonist, and its potency is comparable to PAF C-18 in rabbit platelet aggregation, and to PAF C-16 in the activation of guinea pig macrophages.1 2-thio PAF is a substrate for lysophospholipase II and for PAF-AH,2 and is the substrate used in Cayman’s PAF-AH Assay Kit (Item No. 760901).

1 Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

2 Aarsman, A.J., Neys, F.W., and van den Bosch, H. Catabolism of platelet-activating factor and its acyl analog. Differentiation of the activities of lysophospholipase and platelet-activating-factor acetylhydrolase. Eur J Biochem 200 187-193 (1991).

Formal Name 1-​O-​hexadecyl-​2-​deoxy-​2-​thio-​S-​acetyl-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 96801-55-7
Molecular Formula C26H54NO6PS
Formula Weight 539.8
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOC[C@H]​(COP(=O)​(O)​OCC[N]​(C)​(C)​C)​SC(=O)​C

Background Reading

Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

Aarsman, A.J., Neys, F.W., and van den Bosch, H. Catabolism of platelet-activating factor and its acyl analog. Differentiation of the activities of lysophospholipase and platelet-activating-factor acetylhydrolase. Eur J Biochem 200 187-193 (1991).

2-thio-PAF is available in the following screening library:

Size Price Quantity Subtotal
5 mg $134.00 $0.00
10 mg $255.00 $0.00
25 mg $603.00 $0.00
50 mg $1,072.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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