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2-thio-PAF

Cayman Chemical Item Number 60945

(CAS 96801-55-7)

2-thio-PAF (CAS 96801-55-7)

See more	Lipids (167) Phospholipase (79)

Description

2-thio PAF is an isosteric analog of PAF. It is also a synthetic analog of PAF which contains an acetyl group attached by a thioester bond at the sn-2 position. It functions as a PAF receptor agonist, and its potency is comparable to PAF C-18 in rabbit platelet aggregation, and to PAF C-16 in the activation of guinea pig macrophages.¹ 2-thio PAF is a substrate for lysophospholipase II and for PAF-AH,² and is the substrate used in Cayman’s PAF-AH Assay Kit (Catalog No. 760901).

1 Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

2 Aarsman, A.J., Neys, F.W., and van den Bosch, H. Catabolism of platelet-activating factor and its acyl analog. Differentiation of the activities of lysophospholipase and platelet-activating-factor acetylhydrolase. Eur J Biochem 200 187-193 (1991).

Formal Name	1-O-hexadecyl-2-deoxy-2-thio-S-acetyl-sn-glyceryl-3-phosphorylcholine
CAS Number	96801-55-7
Molecular Formula	C₂₆H₅₄NO₆PS
Formula Weight	539.8
Formulation	A solution in ethanol
Purity	>98%
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OCC[N](C)(C)C)SC(=O)C

Background Reading

Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

Aarsman, A.J., Neys, F.W., and van den Bosch, H. Catabolism of platelet-activating factor and its acyl analog. Differentiation of the activities of lysophospholipase and platelet-activating-factor acetylhydrolase. Eur J Biochem 200 187-193 (1991).

2-thio-PAF is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$134.00		$0.00
10 mg	$255.00		$0.00
25 mg	$603.00		$0.00
50 mg	$1,072.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

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