D-myo-Inositol-1,3,4-triphosphate (sodium salt)

Cayman Chemical Item Number 60972

Ins(1,3,4)-P₃ (sodium salt); 1,3,4-IP₃ (sodium salt)

Description

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.^1,2 D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P₃) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P₃ acts through the inhibition of Ins(3,4,5,6)-P₄ kinase activity to increase the cellular level of Ins(3,4,5,6)-P₄ and thus inhibit calcium-activated chloride channels.³ The levels of Ins(1,3,4)-P₃ are in turn regulated by the levels of cytosolic free calcium.⁴ The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P₃ which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.⁵

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3 Yang, X., Rudolf, M., Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem 274 18973-18980 (1999).

4 Lew, P.D., Monod, A., Krause, K., et al. The role of cytosolic free calcium in the generation of inositol 1,4,5-triphosphate and inositol 1,3,4-triphosphate in HL-60 cells. J Biol Chem 261 13121-13127 (1986).

5 Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

Synonyms

Ins(1,3,4)-P3 (sodium salt)
1,3,4-IP3 (sodium salt)

Formal Name

D-myo-inositol-1,3,4-tris(dihydrogen phosphate), trisodium salt

Molecular Formula

C₆H₁₂O₁₅P₃ · 3Na

Formula Weight

486.0

Formulation

A lyophilized powder

Purity

≥98%

Stability

2 years

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

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O[C@H]1[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]

Background Reading

Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

Lew, P.D., Monod, A., Krause, K., et al. The role of cytosolic free calcium in the generation of inositol 1,4,5-triphosphate and inositol 1,3,4-triphosphate in HL-60 cells. J Biol Chem 261 13121-13127 (1986).

Yang, X., Rudolf, M., Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem 274 18973-18980 (1999).

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

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D-myo-Inositol-1,3,4-triphosphate (sodium salt) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

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D-myo-Inositol-1,3,4-triphosphate (sodium salt)