Cayman Chemical | 1-Oleoyl Lysophosphatidic Acid (sodium salt) | Description • Oleoyl-sn-3-glycerophosphate (sodium salt) (CAS 22556-62-3)

62215 1-Oleoyl Lysophosphatidic Acid (sodium salt)

Oleoyl-sn-3-glycerophosphate (sodium salt) (CAS 22556-62-3)

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1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase.¹ Hydrolysis of the fatty acid at the sn-2 position by PLA₂ yields bioactive LPA. LPA binds to one of four different G-protein linked receptors² to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.¹ 1-Oleoyl lysophosphatidic acid is the most potent of the LPA analogs for calcium mobilization in A431 cells³ and for growth stimulation of a variety of cell lines.⁴

1 Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions. Trends Cell Biol 4 213-219 (1994).

2 Noguchi, K., Ishii, S., Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278(28) 25600-25606 (2003).

3 Jalink, K., Hengeveld, T., Mulder, S., et al. Lysophosphatidic acid-induced Ca2+ mobilization in human A4431 cells: Structure-activity analysis. Biochem J 307 609-616 (1995).

4 van Corven, E.J., van Rijswijk, A., Jalink, K., et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J 281 163-169 (1992).

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Pricing updated 2010-03-19.
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