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2-Linoleoyl Glycerol Exclusive

Cayman Chemical Item Number 62260

2-LG (CAS 3443-82-1)

2-Linoleoyl Glycerol (CAS 3443-82-1)

See more	Endocannabinoids (54) Phospholipase (79) Neuroscience (654)

Description

2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain,¹ and has been characterized as the natural endocannabinoid ligand for the CB₁ receptor.² The congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group is 2-linoleoyl glycerol (2-LG), and this compound also appears in vivo in conjunction with 2-AG.³ Although the intrinsic activity of 2-LG is low, it potentiates the activity of other endocannabinoids, including 2-AG. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release.

1 Sugiura, T., Kodaka, T., Kondo, S., et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma X glioma hybrid NG108-15 cells. Biochem Biophys Res Commun 229 58-64 (1996).

2 Sugiura, T., Kodaka, T., Kondo, S., et al. Is the cannabinoid CB₁ receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. J Biochem 122 890-895 (1997).

3 Ben-Shabat, S., Fride, E., Sheskin, T., et al. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol 353 23-31 (1998).

Synonyms	2-LG
Formal Name	9Z,12Z-octadecadienoic acid, 2-glyceryl ester
CAS Number	3443-82-1
Molecular Formula	C₂₁H₃₈O₄
Formula Weight	354.5
Formulation	A solution in acetonitrile
Purity	>98%
Stability	6 months
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C/C=C\CCCCCCCC(=O)OC(CO)CO

Background Reading

Sugiura, T., Kodaka, T., Kondo, S., et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma X glioma hybrid NG108-15 cells. Biochem Biophys Res Commun 229 58-64 (1996).

Ben-Shabat, S., Fride, E., Sheskin, T., et al. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol 353 23-31 (1998).

Sugiura, T., Kodaka, T., Kondo, S., et al. Is the cannabinoid CB₁ receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. J Biochem 122 890-895 (1997).

2-Linoleoyl Glycerol is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
500 µg	$11.00		$0.00
1 mg	$21.00		$0.00
5 mg	$88.00		$0.00
10 mg	$154.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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