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C-8 Ceramine

Cayman Chemical Item Number 62545

(CAS 170926-06-4)

C-8 Ceramine (CAS 170926-06-4)

See more	Ceramides/Sphingolipids (55)

Description

C-8 ceramine is an analog of C-8 ceramide in which the carbonyl group of the ceramide is replaced by a methylene group. At a concentration of 10 µM, C-8 ceramine induces maximal DNA fragmentation in U937 cells after 6 hours of incubation, compared to 12 hours for C-8 ceramide.¹

1 Karasavvas, N., Erukulla, R.K., Bittman, R., et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. Eur J Biochem 236 729-737 (1996).

Formal Name	N-octylsphingosine
CAS Number	170926-06-4
Molecular Formula	C₂₆H₅₃NO₂
Formula Weight	411.7
Formulation	A crystalline solid
Purity	>98%
Stability	6 months
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCC/C=C/C(O)[C@H](CO)NCCCCCCCCC

Background Reading

Karasavvas, N., Erukulla, R.K., Bittman, R., et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. Eur J Biochem 236 729-737 (1996).

C-8 Ceramine is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$43.00		$0.00
5 mg	$194.00		$0.00
10 mg	$344.00		$0.00
50 mg	$1,505.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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