62570  Sphingosine-1-phosphate

S1P (CAS 26993-30-6)

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• See more Ceramides/Sphingolipids; Apoptosis; Immunology

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase. Like many products of sphingomyelin, it exhibits a wide range of biological activities. Not only does it enhance cell growth,1 but it can inhibit the normal apoptotic response to a variety of stimuli.2 The ability of PKC to block apoptosis is likely due to the formation of S1P. S1P stimulates MAPK and counteracts the ceramide-induced activation of SAPK and JNK.2 It also increases intracellular calcium levels by both the liberation of calcium from internal stores3 and through activation of a Gi protein-coupled receptor resulting in the opening of a cell surface calcium channel.4
1  Olivera, A., Spiegel, S. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365 557-560 (1993).
2  Cuvillier, O., Pirianov, G., Kleuser, B., et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381 800-803 (1996).
3  Mattie, M., Brooker, G., Spiegel, S. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J Biol Chem 269 3181-3188 (1994).
4  van Koppen, C.J., zu Heringdorf, D.M., Laser, K.T., et al. Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J Biol Chem 271 2082-2087 (1996).


Purchase 62570 Sphingosine-1-phosphate

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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