Cayman Chemical | N,N-Dimethylsphingosine | Description (CAS 119567-63-4)

62575 N,N-Dimethylsphingosine

(CAS 119567-63-4)

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N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase. It is a natural metabolite of sphingosine in some cancer cell lines and tissues.¹ N,N-Dimethylsphingosine inhibited U937 cell sphingosine kinase with a K_i value of 3.1 µM.² N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C.

1 Yatomi, Y., Ruan, F., Megidish, T., et al. N,N-Dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35 626-633 (1996).

2 Edsall, L.C., Van Brocklyn, J.R., Cuvillier, O., et al. N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37 12892-12898 (1998).

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Pricing updated 2010-03-19.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.