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Oleyl Trifluoromethyl Ketone

Cayman Chemical Item Number 62640

OTK; Heptadecyl Trifluoromethyl Ketone (CAS 177987-23-4)

Oleyl Trifluoromethyl Ketone (CAS 177987-23-4)

See more	Neuroscience (654)

Description

Oleyl trifluoromethyl ketone is an analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone. It is a potent inhibitor of FAAH, in both human and rat. In transfected Cos-7 cells, 10 µM oleyl trifluoromethyl ketone inhibits 95.7% of human FAAH activity and 94.8% of rat FAAH activity.^1,2

1 Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).

2 Giang, D.K., and Cravatt, B.F. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci USA 94 2238-2242 (1997).

Synonyms	OTK Heptadecyl Trifluoromethyl Ketone
Formal Name	1,1,1-trifluoro-10Z-nonadecen-2-one
CAS Number	177987-23-4
Molecular Formula	C₁₉H₃₃F₃O
Formula Weight	334.5
Formulation	A solution in ethanol
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCC/C=C\CCCCCCCC(=O)C(F)(F)F

Background Reading

Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).

Giang, D.K., and Cravatt, B.F. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci USA 94 2238-2242 (1997).

Oleyl Trifluoromethyl Ketone is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$9.00		$0.00
5 mg	$41.00		$0.00
10 mg	$72.00		$0.00
50 mg	$315.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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