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Palmityl Trifluoromethyl Ketone

Cayman Chemical Item Number 62650

PTK; Pentadeca Trifluoromethyl Ketone (CAS 141022-99-3)

Palmityl Trifluoromethyl Ketone (CAS 141022-99-3)

See more	Phospholipase (79) Neuroscience (725)

Description

PTK is an analog of palmitic acid in which the COOH group is replaced by trifluoromethyl ketone. In P388D1 cells, PTK inhibits iPLA₂ activity with an IC₅₀ value of 3.8 µM.¹ A related compound, ATK is a less potent inhibitor of iPLA₂ with an IC₅₀ value of 15 µM.¹ PTK also inhibits the activity of cPLA₂ with an IC₅₀ value almost identical to that of ATK.²

1 Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A₂ by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270 445-450 (1995).

2 Conde-Frieboes, K., Reynolds, L.J., Lio, Y., et al. Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A₂. J Am Chem Soc 118 5519-5525 (1996).

Synonyms	PTK Pentadeca Trifluoromethyl Ketone
Formal Name	1,1,1-trifluoro-2-heptadecanone
CAS Number	141022-99-3
Molecular Formula	C₁₇H₃₁F₃O
Formula Weight	308.4
Formulation	A solution in ethanol
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCC(=O)C(F)(F)F

Background Reading

Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A₂ by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270 445-450 (1995).

Conde-Frieboes, K., Reynolds, L.J., Lio, Y., et al. Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A₂. J Am Chem Soc 118 5519-5525 (1996).

Palmityl Trifluoromethyl Ketone is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$9.00		$0.00
5 mg	$36.00		$0.00
10 mg	$54.00		$0.00
25 mg	$101.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Arachidonyl Trifluoromethyl Ketone

sPLA₂ Assay Kit

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