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Thioetheramide-PC

Cayman Chemical Item Number 62750

1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine (CAS 116457-99-9)

Thioetheramide-PC (CAS 116457-99-9)

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Description

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).1,2 The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.1

1 Yu, L., Deems, R.A., Hajdu, J., et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J Biol Chem 265 2657-2664 (1990).

2 Plesniak, L.A., Boegeman, S.C., Segelke, B.W., et al. Interaction of phospholipase A2 with thioether amide containing phospholipid analogues. Biochemistry 32 5009-5016 (1993).

Synonyms
  • 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
Formal Name 1,​2-​dideoxy-​1-​(S-​hexadecyl)thio-​2-​(N-​hexadecanoyl)amino-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 116457-99-9
Molecular Formula C40H83N2O5PS
Formula Weight 735.1
Formulation A solution in ethanol
Purity >95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCSC[C@H]​(COP(=O)​(O)​OCC[N]​(C)​(C)​C)​NC(=O)​CCCCCCCCCCCCCCC

Background Reading

Yu, L., Deems, R.A., Hajdu, J., et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J Biol Chem 265 2657-2664 (1990).

Plesniak, L.A., Boegeman, S.C., Segelke, B.W., et al. Interaction of phospholipase A2 with thioether amide containing phospholipid analogues. Biochemistry 32 5009-5016 (1993).

Thioetheramide-PC is available in the following screening library:

Size Price Quantity Subtotal
1 mg $22.00 $0.00
5 mg $99.00 $0.00
10 mg $176.00 $0.00
25 mg $385.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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