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Thioetheramide-PC

Cayman Chemical Item Number 62750

1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine (CAS 116457-99-9)

Thioetheramide-PC (CAS 116457-99-9)

See more	Inhibitors (493) Phospholipids (58)

Description

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A₂ (sPLA₂).^1,2 The IC₅₀ value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.¹ In addition to binding to the catalytic site of sPLA₂, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.¹

1 Yu, L., Deems, R.A., Hajdu, J., et al. The interaction of phospholipase A₂ with phospholipid analogues and inhibitors. J Biol Chem 265 2657-2664 (1990).

2 Plesniak, L.A., Boegeman, S.C., Segelke, B.W., et al. Interaction of phospholipase A₂ with thioether amide containing phospholipid analogues. Biochemistry 32 5009-5016 (1993).

Synonyms	1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
Formal Name	1,2-dideoxy-1-(S-hexadecyl)thio-2-(N-hexadecanoyl)amino-sn-glyceryl-3-phosphorylcholine
CAS Number	116457-99-9
Molecular Formula	C₄₀H₈₃N₂O₅PS
Formula Weight	735.1
Formulation	A solution in ethanol
Purity	>95%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCSC[C@H](COP(=O)(O)OCC[N](C)(C)C)NC(=O)CCCCCCCCCCCCCCC

Background Reading

Yu, L., Deems, R.A., Hajdu, J., et al. The interaction of phospholipase A₂ with phospholipid analogues and inhibitors. J Biol Chem 265 2657-2664 (1990).

Plesniak, L.A., Boegeman, S.C., Segelke, B.W., et al. Interaction of phospholipase A₂ with thioether amide containing phospholipid analogues. Biochemistry 32 5009-5016 (1993).

Thioetheramide-PC is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$22.00		$0.00
5 mg	$99.00		$0.00
10 mg	$176.00		$0.00
25 mg	$385.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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