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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PAz-PC

Cayman Chemical Item Number 62924

Azelaoyl PC; 1-Palmitoyl-2-Azelaoyl PC (CAS 117746-89-1)

PAz-PC (CAS 117746-89-1)

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Description

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.1 Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.2 PAz-PC is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.3

1 Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105(8) 1095-1108 (2000).

2 Podrez, E.A., Batyreva, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem 277 (41) 38517-38523 (2002).

3 Itabe, H., Kudo, I., and Inoue, K. Preferential hydrolysis of oxidized phospholipids by peritoneal fluid of rats treated with casein. Biochim Biophys Acta 963 192-200 (1998 Aug 16).

Synonyms
  • Azelaoyl PC
  • 1-Palmitoyl-2-Azelaoyl PC
Formal Name 1-​O-​hexadecanoyl-​2-​O-​(9-​carboxyoctanoyl)-​sn-​glyceryl-​3-​phosphocholine
CAS Number 117746-89-1
Molecular Formula C33H64NO10P
Formula Weight 665.8
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=P([O-]​)​(OCC[N+]​(C)​(C)​C)​OC[C@H]​(OC(CCCCCCCC(O)​=O)​=O)​COC(CCCCCCCCCCCCCCC)​=O

Background Reading

Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105(8) 1095-1108 (2000).

Podrez, E.A., Batyreva, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem 277 (41) 38517-38523 (2002).

Itabe, H., Kudo, I., and Inoue, K. Preferential hydrolysis of oxidized phospholipids by peritoneal fluid of rats treated with casein. Biochim Biophys Acta 963 192-200 (1998 Aug 16).

PAz-PC is available in the following screening library:

Size Price Quantity Subtotal
1 mg $33.00 $0.00
5 mg $149.00 $0.00
10 mg $264.00 $0.00
25 mg $578.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-09. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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