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DMAPP (ammonium salt)

Cayman Chemical Item Number 63180

Dimethylallyl Pyrophosphate (ammonium salt) (CAS 1186-30-7)

DMAPP (ammonium salt) (CAS 1186-30-7)

See more	Lipids (167)

Description

Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.^1,2 Farnesylation is essential for the function of a number of proteins involved in signal transduction.^3,4

1 Barnard, G.F., and Popják, G. Human liver prenyltransferase and its characterization. Biochim Biophys Acta 661 87-99 (1981).

2 Laskovics, F.M., and Poulter, C.D. Prenyltransferase: Determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments. Biochemistry 20 1893-1901 (1981).

3 Hohl, R.J., Lewis, K.A., Cermak, D.M., et al. Stereochemistry-dependent inhibition of Ras farnesylation by farnesylphosphonic acids. Lipids 33 39-46 (1998).

4 Rando, R.R. Chemical biology of protein isoprenylation/methylation. Biochim Biophys Acta 1300 5-16 (1996).

Synonyms	Dimethylallyl Pyrophosphate (ammonium salt)
Formal Name	3-methyl-2-butenyl-1-diphosphoric acid, triammonium salt
CAS Number	1186-30-7
Molecular Formula	C₅H₁₂O₇P₂ · 3(NH₄)
Formula Weight	300.2
Formulation	A crystalline solid
Purity	≥95%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard [O-]P([O-])(OP([O-])(OC/C=C(C)\C)=O)=O.[NH4+].[NH4+].[NH4+]

Background Reading

Rando, R.R. Chemical biology of protein isoprenylation/methylation. Biochim Biophys Acta 1300 5-16 (1996).

Laskovics, F.M., and Poulter, C.D. Prenyltransferase: Determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments. Biochemistry 20 1893-1901 (1981).

Barnard, G.F., and Popják, G. Human liver prenyltransferase and its characterization. Biochim Biophys Acta 661 87-99 (1981).

Hohl, R.J., Lewis, K.A., Cermak, D.M., et al. Stereochemistry-dependent inhibition of Ras farnesylation by farnesylphosphonic acids. Lipids 33 39-46 (1998).

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Size	Price	Quantity	Subtotal
500 µg	$55.00		$0.00
1 mg	$105.00		$0.00
5 mg	$440.00		$0.00
10 mg	$770.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(E)-C-HDMAPP (ammonium salt) Exclusive

α-hydroxy Farnesyl Phosphonic Acid

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