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N-acetyl-S-farnesyl-L-Cysteine

Cayman Chemical Item Number 63270

AFC (CAS 135304-07-3)

N-acetyl-S-farnesyl-L-Cysteine (CAS 135304-07-3)

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Description

N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).1,2 Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

1 Volker, C., Lane, P., Kwee, C., et al. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett 295 189-194 (1991).

2 Pérez-Sala, D., Gilbert, B.A., Tan, E.W., et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem J 284 835-840 (1992).

Synonyms
  • AFC
Formal Name N-​acetyl-​S-​(3,​7,​11-​trimethyl-​2E,​6E,​10-​dodecatrienyl)-​L-​cysteine
CAS Number 135304-07-3
Molecular Formula C20H33NO3S
Formula Weight 367.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(N([C@H]​(C(O)​=O)​CSC/C=C(CC/C=C(C)​/CC/C=C(C)​/C)​\C)​[H]​)​=O

Background Reading

Volker, C., Miller, R.A., McCleary, W.R., et al. Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction. J Biol Chem 266 21515-21522 (1991).

Tan, E.W., Perez-Sala, D., Canada, F.J., et al. Identifying the recognition unit for G protein methylation. J Biol Chem 266 10719-10722 (1991).

Volker, C., Lane, P., Kwee, C., et al. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett 295 189-194 (1991).

Pérez-Sala, D., Gilbert, B.A., Tan, E.W., et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem J 284 835-840 (1992).

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N-acetyl-S-farnesyl-L-Cysteine is available in the following screening library:

Size Price Quantity Subtotal
1 mg $15.00 $0.00
5 mg $68.00 $0.00
10 mg $120.00 $0.00
25 mg $263.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

N-acetyl-S-geranylgeranyl-L-Cysteine
S-Farnesyl Thioacetic Acid
α-hydroxy Farnesyl Phosphonic Acid

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