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N-acetyl-S-farnesyl-L-Cysteine

Cayman Chemical Item Number 63270

AFC (CAS 135304-07-3)

N-acetyl-S-farnesyl-L-Cysteine (CAS 135304-07-3)

See more	Lipids (167)

Description

N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).^1,2 Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

1 Volker, C., Lane, P., Kwee, C., et al. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett 295 189-194 (1991).

2 Pérez-Sala, D., Gilbert, B.A., Tan, E.W., et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem J 284 835-840 (1992).

Synonyms	AFC
Formal Name	N-acetyl-S-(3,7,11-trimethyl-2E,6E,10-dodecatrienyl)-L-cysteine
CAS Number	135304-07-3
Molecular Formula	C₂₀H₃₃NO₃S
Formula Weight	367.5
Formulation	A solution in ethanol
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC(N([C@H](C(O)=O)CSC/C=C(CC/C=C(C)/CC/C=C(C)/C)\C)[H])=O

Background Reading

Volker, C., Miller, R.A., McCleary, W.R., et al. Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction. J Biol Chem 266 21515-21522 (1991).

Tan, E.W., Perez-Sala, D., Canada, F.J., et al. Identifying the recognition unit for G protein methylation. J Biol Chem 266 10719-10722 (1991).

Volker, C., Lane, P., Kwee, C., et al. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett 295 189-194 (1991).

Pérez-Sala, D., Gilbert, B.A., Tan, E.W., et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem J 284 835-840 (1992).

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N-acetyl-S-farnesyl-L-Cysteine is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$15.00		$0.00
5 mg	$68.00		$0.00
10 mg	$120.00		$0.00
25 mg	$263.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

N-acetyl-S-geranylgeranyl-L-Cysteine

S-Farnesyl Thioacetic Acid

α-hydroxy Farnesyl Phosphonic Acid

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