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MiltefosineCayman Chemical Item Number 63280 HePC (CAS 58066-85-6) 
Miltefosine (CAS 58066-85-6)
Description
Miltefosine is an inhibitor of CTP:phosphocholine cytidylyl transferase and has antimetastatic properties.1,2,3 At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively.4 The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control.4 Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood.5
1
Geilen, C.C., Wieder, T., and Reutter, W. Hexadecylphosphocholine inhibits translocation of CTP: Choline-
2
Wieder, T., Geilen, C.C., and Reutter, W. Antagonism of phorbol-
3
Geilen, C.C., Haase, R., Buchner, K., et al. The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-
4
Wieder, T., Orfanos, C.E., and Geilen, C.C. Induction of ceramide- 5 Sundar, S., Jha, T.K., Thakur, C.P., et al. Oral miltefosine for indian visceral leishmaniasis. N Engl J Med 347 (22) 1739-1746 (2002).
Background ReadingGeilen, C.C., Haase, R., Buchner, K., et al. The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester- Wieder, T., Orfanos, C.E., and Geilen, C.C. Induction of ceramide- Wieder, T., Geilen, C.C., and Reutter, W. Antagonism of phorbol- Geilen, C.C., Wieder, T., and Reutter, W. Hexadecylphosphocholine inhibits translocation of CTP: Choline- Sundar, S., Jha, T.K., Thakur, C.P., et al. Oral miltefosine for indian visceral leishmaniasis. N Engl J Med 347 (22) 1739-1746 (2002). Show all 5 Hide all but first 3Miltefosine is available in the following screening library: |
This product is available in custom sizes and/or larger quantities. Please contact our Sales Department for a quote or to purchase. Pricing updated 2012-05-26. Prices are subject to change without notice. To ask for assistance with one of our products please contact a Technical Support Scientist. Warning This product is not for human or veterinary use. Related Products
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