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Cytotrienin A

Cayman Chemical Item Number 63500

(CAS 189010-85-3)

Cytotrienin A (CAS 189010-85-3)

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Description

Cytotrienin A is an anti-tumor agent isolated from Steptomyces species. It induces apoptosis in human promyelocytic leukemia HL-60 cells within four hours of treatment at a concentration of 100 ng/ml via activation of reactive oxygen species, caspase-3, and p36 myelin basic protein kinase, as well as through a separate pathway via activation of JNK.1,2

1 Kakeya, H., Onose, R., and Osada, H. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res 58 4888-4894 (1998).

2 Watabe, M., Kakeya, H., Onose, R., et al. Activation of MST/Krs and c-jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis. J Biol Chem 275(12) 8766-8771 (2000).

Formal Name 1-​[(1-​cyclohexen-​1-​ylcarbonyl)amino]-​15R,​22,​24-​trihydroxy-​5R-​methoxy-​14R,​16Z-​dimethyl-​3-​oxo-​2-​azabicyclo[18.3.1]tetracosa-​1(24),​6E,​8E,​10E,​16,​20,​22-​heptaen-​13S-​yl ester-​cyclopropanecarboxylic acid
CAS Number 189010-85-3
Molecular Formula C37H48N2O8
Formula Weight 648.8
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COC1C=CC=CC=CCC(OC(=O)​C2(CC2)​NC(=O)​C2=CCCCC2)​C(C)​C(O)​C(=CCCc2cc(O)​cc(NC(=O)​C1)​c2O)​C

Background Reading

Kakeya, H., Onose, R., and Osada, H. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res 58 4888-4894 (1998).

Watabe, M., Kakeya, H., Onose, R., et al. Activation of MST/Krs and c-jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis. J Biol Chem 275(12) 8766-8771 (2000).
Size Price Quantity Subtotal
100 µg $277.00 $0.00
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Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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