See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Cytotrienin A

Cayman Chemical Item Number 63500

(CAS 189010-85-3)

Cytotrienin A (CAS 189010-85-3)

See more

Description

Cytotrienin A is an anti-tumor agent isolated from Steptomyces species. It induces apoptosis in human promyelocytic leukemia HL-60 cells within four hours of treatment at a concentration of 100 ng/ml via activation of reactive oxygen species, caspase-3, and p36 myelin basic protein kinase, as well as through a separate pathway via activation of JNK.1,2

1 Kakeya, H., Onose, R., and Osada, H. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res 58 4888-4894 (1998).

2 Watabe, M., Kakeya, H., Onose, R., et al. Activation of MST/Krs and c-jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis. J Biol Chem 275(12) 8766-8771 (2000).

Formal Name 1-​[(1-​cyclohexen-​1-​ylcarbonyl)amino]-​15R,​22,​24-​trihydroxy-​5R-​methoxy-​14R,​16Z-​dimethyl-​3-​oxo-​2-​azabicyclo[18.3.1]tetracosa-​1(24),​6E,​8E,​10E,​16,​20,​22-​heptaen-​13S-​yl ester-​cyclopropanecarboxylic acid
CAS Number 189010-85-3
Molecular Formula C37H48N2O8
Formula Weight 648.8
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
COC1C=CC=CC=CCC(OC(=O)​C2(CC2)​NC(=O)​C2=CCCCC2)​C(C)​C(O)​C(=CCCc2cc(O)​cc(NC(=O)​C1)​c2O)​C

Background Reading

Kakeya, H., Onose, R., and Osada, H. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res 58 4888-4894 (1998).

Watabe, M., Kakeya, H., Onose, R., et al. Activation of MST/Krs and c-jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis. J Biol Chem 275(12) 8766-8771 (2000).
Size Price Quantity Subtotal
100 µg $277.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Apoptotic Blebs Assay Kit
Caspase-3 Fluorescence Assay Kit
Caspase-3 (human) Polyclonal Antibody
FK-506
Valinomycin
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?